EPA Faces Ongoing Mutagenicity Challenges Absent Assessment Framework

EPA's National Center for Environmental Assessment (NCEA) is continuing to face a series of challenges regarding mutagenicity and its use of mode of action (MOA) data, information that informs risk assessors how a chemical moves through the body and causes effects and also determines how stringently chemicals' carcinogenicity is assessed under the agency's cancer risk assessment guidelines. These issues are critical for NCEA, which operates and maintains EPA's Integrated Risk Information System (IRIS), the agency's influential database of some 550...