Stakeholders Voice Cautious Optimism On EPA’s Reworked IRIS Manual

EPA’s long-awaited update to its Integrated Risk Information System (IRIS) handbook is drawing measured praise from academics and industry but also targeted concerns, particularly regarding elements of its systematic review approach -- which the National Academy of Sciences (NAS) has touted as a model for EPA’s TSCA program. A systematic review expert with the Program on Reproductive Health and the Environment (PRHE) at the University of California San Francisco praised the handbook’s approach to that discipline in a recent interview,...